Effect of Aging on Glucose Homeostasis Accelerated deterioration of -cell function in individuals with impaired glucose tolerance

RESULTS — As expected, both phases of insulin release and insulin sensitivity were reduced in individuals with IGT (all P 0.01). Insulin sensitivity was not independently correlated with age in either group. In people with NGT, the disposition index for firstand second-phase insulin release decreased similarly at a rate of 0.7% per year. In people with IGT, the disposition indexes for firstand second-phase insulin release decreased at greater rates ( 2.2 and 1.4% per year, P 0.002 and 0.009, respectively, vs. NGT), with the decrease in first phase being greater than that of second phase (P 0.025).